解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::In rodents, oligodendrocytes and myelinating Schwann cells express connexin32 (Cx32) and Cx29, which have different localizations in the two cell types. We show here that, in contrast to Cx32, Cx29 does not form gap junction plaques or functional gap junctions in transfected cells. Furthermore, when expressed together...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21561
更新日期:2008-04-01 00:00:00
abstract::Localization of acetylcholine receptors (AChRs) to the postsynaptic region of muscle is mediated in part by transcriptional mechanisms, because the genes encoding AChR subunits are transcribed selectively in synaptic myofiber nuclei. Neuregulin-1 (NRG-1) is a synaptic signal and induces transcription of AChRs in muscl...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21563
更新日期:2008-04-01 00:00:00
abstract::Amyloid beta-peptide (A beta) likely causes functional alterations in neurons well prior to their death. Nuclear factor-kappaB (NF-kappaB), a transcription factor that is known to play important roles in cell survival and apoptosis, has been shown to be modulated by A beta in neurons and glia, but the mechanism is unk...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21548
更新日期:2008-03-01 00:00:00
abstract::N-cadherin and beta-catenin are involved in cell adhesion and cell cycle in tumor cells and neural crest. Both are expressed at key stages of Schwann cell (SC) development, but little is known about their function in the SC lineage. We studied the role of these molecules in adult rat derived SC-embryonic dorsal root g...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21528
更新日期:2008-03-01 00:00:00
abstract::The analysis of proteins in damaged myelin is crucial to clarify the mechanisms of dysmyelination and demyelination. In the present study, proteomic analysis of myelin using a modified two-dimensional electrophoresis (2-DE) method was carried out to obtain a better understanding of myelin biology. Although standard 2-...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21547
更新日期:2008-03-01 00:00:00
abstract::Withdrawal of serum from cell cultures constitutes a useful model for the study of mechanisms involved in the regulation of Akt function in vitro. However, there have been several reports of changes in Akt activity that are not fully explained by the current model of phosphatidylinositol 3'-kinase (PI3K)/Akt signaling...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21516
更新日期:2008-02-15 00:00:00
abstract::The type 1 metabotropic glutamate receptor (mGluR1) plays an import role in the synaptic physiology and development of cerebellar Purkinje neurons. mGluR1 expression occurs early in the developmental program of Purkinje neurons, at an age that precedes expression of the dendritic structure. Few studies have investigat...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21493
更新日期:2008-02-01 00:00:00
abstract::Rho-GTPase has been implicated in the apoptosis of many cell types, including neurons, but the mechanism by which it acts is not fully understood. Here, we investigate the roles of Rho and ROCK in apoptosis during transplantation of embryonic stem cell-derived neural precursor cells. We find that dissociation of neura...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21502
更新日期:2008-02-01 00:00:00
abstract::Parkinson's disease (PD) is a movement disorder characterized by a progressive loss of nigrostriatal dopaminergic neurons. Microglia activation and neuroinflammation have been associated with the pathogenesis of PD. Indeed, cytokines have been proposed as candidates that mediate the apoptotic cell death of dopaminergi...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21503
更新日期:2008-02-01 00:00:00
abstract::Motoneuron number and expression of cytoplasmic RNA and ribosomal RNA (rRNA) gene transcription activity in the facial nucleus were examined quantitatively and chronologically for up to 4 weeks in rats after facial nerve axotomy and avulsion in order to elucidate interrelationships in axonal changes. The right facial ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21495
更新日期:2008-02-01 00:00:00
abstract::Programmed cell death involving gene regulation and de novo protein synthesis is a major component of both normal development and a number of disease conditions. Hence, knowledge of its mechanisms, especially transcription factors, that regulate expression of the genes involved in neurodegenerative disorders is of gre...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21469
更新日期:2008-01-01 00:00:00
abstract::5-Hydroxyoxindole has been identified as a urinary metabolite of indole, which is produced from tryptophane via the tryptophanase activity of gut bacteria. We have demonstrated recently that 5-hydroxyoxindole is an endogenous compound in blood and tissues of mammals, including humans. To date, 5-hydroxyoxindole's role...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21475
更新日期:2008-01-01 00:00:00
abstract::Mounting evidence has demonstrated that the microenvironment of stem/progenitor cells plays an important role in their proliferation and commitment to their fate. However, it remains unclear how all elements, such as astrocytes, microglia, extracellular matrix molecules, soluble factors, and their cross-talk interacti...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21454
更新日期:2008-01-01 00:00:00
abstract::Grafting fetal ventral mesencephalon has been utilized to alleviate the symptoms of Parkinson's disease. One obstacle in using this approach is the limited outgrowth from the transplanted dopamine neurons. Thus, it is important to evaluate factors that promote outgrowth from fetal dopamine neurons. Proteoglycans (PGs)...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21465
更新日期:2008-01-01 00:00:00
abstract::We have performed proteomic analysis in the cerebrospinal fluid in an animal model of Parkinson's disease induced by axotomy of the medial forebrain bundle. In this model, the degeneration of dopaminergic neurons was completed in 14 days, with a loss of about 50% dopaminergic neurons in the substantia nigra and a loss...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21452
更新日期:2007-12-01 00:00:00
abstract::Regulatory factor X4 variant 3 (RFX4_v3) is a recently identified transcription factor specifically expressed in the brain. Gene disruption in mice demonstrated that interruption of a single allele (heterozygous, +/-) prevented formation of the subcommissural organ (SCO), resulting in congenital hydrocephalus, whereas...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/jnr.21356
更新日期:2007-12-01 00:00:00
abstract::Chronic lead exposure during development is known to produce learning deficits. In the present study, we investigated the effects of developmental exposure to lead on spatial memory, as shown in the Morris water maze, and on expression of inducible cyclooxygenase-2 protein in the hippocampi of male rats. Rats were sep...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21423
更新日期:2007-11-01 00:00:00
abstract::Although protein kinase Cdk5-p35 is important in many aspects of the development and function of the central nervous system, relatively little is known about its regulation. In the present study, we examined the relationship between the association of this kinase with membranes and its activity in perinatal and adult ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21438
更新日期:2007-11-01 00:00:00
abstract::The tissue- and cell-specific expression of three neutral glycosphingolipids, gangliotetraosylceramide (GA1), gangliopentaosylceramide (GalNAc-GA1), and the novel 3-O-acetyl-sphingosine-series glycolipid (FMC-5), were examined with monospecific polyclonal antibodies. Immunohistochemical studies of rodent brain cross-s...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21419
更新日期:2007-10-01 00:00:00
abstract::Noradrenalin (NA) regulates the expression of arginine-vasopressin (AVP) and oxytocin (OT) by magnocellular neurons in the supraoptic nucleus (SON) of the hypothamalus. Nitric oxide (NO) may be one of the factors involved in the NA signaling pathway regulating AVP and OT expression. To test this possibility, we used a...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21394
更新日期:2007-10-01 00:00:00
abstract::Neural precursor cells, including neural stem and progenitor cells, in the subventricular zone (SVZ) are the main targets for cytomegalovirus (CMV) infection in developing brains. The neural precursor cells in the SVZ of the adult brain have been reported to respond by proliferating after infusion with epidermal growt...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21410
更新日期:2007-10-01 00:00:00
abstract::In contrast to mammals, teleost fish are able to regrow severed long-range projection axons in the central nervous system (CNS), leading to recovery of function. The optic projection in teleost fish is used to study neuron-intrinsic and environmental molecular factors that determine successful axon regrowth and naviga...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/jnr.21121
更新日期:2007-09-01 00:00:00
abstract::Nuclear inclusions formed by proteins with expanded polyglutamine tracts are found in several neurodegenerative diseases. The effect of nuclear inclusions formed by these disease proteins on the functional organization of the nucleus is only partially understood. In particular, it is not known whether polyglutamine di...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21369
更新日期:2007-08-15 00:00:00
abstract::The higher prevalence and risk for Alzheimer's disease in women relative to men has been partially attributed to the precipitous decline in gonadal hormone levels that occurs in women following the menopause. Although considerable attention has been focused on the consequence of estrogen loss, and thus estrogen's neur...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21370
更新日期:2007-08-15 00:00:00
abstract::Because there is a strong correlation between tuberous sclerosis and autism, we used a tuberous sclerosis model (Eker rat) to test the hypothesis that these animals would have an altered regional cerebral O2 consumption that might be associated with autism. We also examined whether the altered cerebral O2 consumption ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21378
更新日期:2007-08-15 00:00:00
abstract::Acute intoxication with large ammonia doses leads to activation of NMDA receptors in the brain, resulting in oxidative stress and disturbance of mitochondrial function. Altered mitochondrial function is a crucial step in some mechanisms of cellular apoptosis. This study assesses whether ammonia intoxication in vivo le...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21385
更新日期:2007-08-15 00:00:00
abstract::Oxidative stress, neuroinflammation, and excitotoxicity are frequently considered distinct but common hallmarks of several neurological disorders, including Parkinson's disease, amyotrophic lateral sclerosis, multiple sclerosis, and Alzheimer's disease. Although neuron degeneration and death are the ultimate consequen...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/jnr.21325
更新日期:2007-08-01 00:00:00
abstract::Despite the accumulating data on the molecular and cell biological characteristics of neural stem/progenitor cells, their electrophysiological properties are not well understood. In the present work, changes in the membrane properties and current profiles were investigated in the course of in vitro-induced neuron form...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21282
更新日期:2007-06-01 00:00:00
abstract::The neurotrophin receptor p75 (p75NTR) is expressed by both neurons and glia. Nerve injury triggers up-regulation of p75NTR in Schwann cells (SC) but not in central glia. In contrast to neuronal p75NTR, which mediates negative signals from myelin-associated proteins resulting in neurite collapse, glial p75NTR may play...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/jnr.21220
更新日期:2007-06-01 00:00:00
abstract::With the use of an antiserum directed against the human smooth muscle-associated protein 8 (SMAP8) fragment SMAP8(98-138), Western blot and immunohistochemical studies revealed SMAP8 expression in the rat brain. A band with a molecular size of about 45 kDa was detected in tissues from the rat hypothalamus and a weaker...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21315
更新日期:2007-06-01 00:00:00
abstract::Despite a large body of literature on the nociceptin (NC) opioid system in pain modulation, the mechanism of action of NC remains largely unexplored. Here, we investigated the role and mode of action of the spinal NC system in inflammatory pain. Preemptive intrathecal administration of NC attenuated thermal hyperalges...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21272
更新日期:2007-05-15 00:00:00
abstract::The c-Jun N-terminal kinase (JNK) is induced by cerebral ischemia and injurious blood components acutely after subarachnoid hemorrhage (SAH). We hypothesized that inhibition of JNK will prevent damage to the neurovascular unit in the early brain injury period after SAH. Ninety-nine male SD rats (300-350 g) were random...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21281
更新日期:2007-05-15 00:00:00
abstract::Chloride efflux is known to be involved in the progression of apoptosis in various cell types. We have recently shown that the volume-sensitive outwardly rectifying (VSOR) anion channel serves as the pathway for apoptotic chloride efflux in some cells. In the present study, we tested the neuroprotective effects of dru...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21279
更新日期:2007-05-15 00:00:00
abstract::Phencyclidine (PCP) is a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist. Several studies have demonstrated that chronic NMDA receptor antagonist treatment in humans and animals can cause long-term behavioral changes that are reminiscent of negative and cognitive schizophrenia-like symptoms. The muscari...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21247
更新日期:2007-05-01 00:00:00
abstract::Heat shock protein 60 (HSP60) and HSP10 are mitochondrial chaperonin proteins and are responsible for the folding of newly imported proteins and 13 polypeptides encoded by mitochondrial DNA. The expressions of HSP60 and HSP10 are regulated simultaneously because these genes are localized head to head on chromosome, se...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21236
更新日期:2007-05-01 00:00:00
abstract::Dorsal root ganglia (DRG) neurons connect the spinal cord and uterine cervix, and are activated at parturition with subsequent stimulation of secondary neurons in the spinal dorsal horn and autonomic areas. Neuropeptide neurotransmitters and receptors have been studied in these areas, but amino acid transmitters, e.g....
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21225
更新日期:2007-05-01 00:00:00
abstract::Chondroitinase ABC (Ch'ase ABC) is a bacterial lyase that degrades chondroitin sulfate (CS), dermatan sulfate, and hyaluronan glycosaminoglycans (GAGs). This enzyme has received significant attention as a potential therapy for promoting central nervous system and peripheral nervous system repair based on its degradati...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21199
更新日期:2007-04-01 00:00:00
abstract::Cisplatin is a highly effective chemotherapeutic agent but with significant ototoxic side effects. Apoptosis is an important mechanism of cochlear hair cell loss following exposure to an ototoxic level of cisplatin. The present study investigated the effects of the cannabinoid receptor 2 (CB2) ligand JWH-015 on cispla...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21168
更新日期:2007-03-01 00:00:00
abstract::The high circulating levels of leptin in neonatal rodents do not seem to be regulating energy balance at this age, but rather may play an important role for brain development. We tested the hypothesis that high neonatal leptin levels modify hippocampal function and production of synaptic proteins with possible long-te...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21173
更新日期:2007-03-01 00:00:00
abstract::Biology of GnRH neurons is critically dependent on extracellular Ca(2+) (Ca(2+) (o)). We evaluated differences in gene expression patterns with low and high Ca(2+) (o) in an immortalized GnRH neuron line, GT1-7 cells. Mouse global oligonucleotide microarray was used to evaluate transcriptional differences among the ge...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21177
更新日期:2007-03-01 00:00:00